AAOS ''Treatment of Osteoarthritis of the Knee”: Summary of recommendations.

This summary contains a list of the evidence based treatment recommendations for knee OA and includes only less invasive alternatives to knee replacement. Full text available.
I have summarized it and listed specific interventions with strenght of evidence provided. 
  1. Exercise – strong evidence for effectiveness
  2. NSAIDs – strong evidence for
  3. Acupuncture – strong evidence against
  4. Glucosamine and chondroitin – strong evidence against
  5. Hyaluronic acid injections – strong evidence against
  6. Arthroscopy with lavage and debridement – strong evidence against
  7. Weight loss – moderate evidence for
  8. Needle lavage – moderate evidence against
  9. Lateral wedge insoles – moderate evidence against
  10. Physical agents (TENS, ultrasound, etc.) – inconclusive
  11. Manual therapy (chiropractic, massage) – inconclusive
  12. Valgus-directing force brace – inconclusive
  13. Acetaminophen, opioids, pain patches – inconclusive 
  14. Intraarticular corticosteroid injections – inconclusive
  15. Growth factor injections and/or platelet-rich plasma – inconclusive
  16. Partial meniscectomy in osteoarthritis patients with torn meniscus – inconclusive
  17. Valgus-producing proximal tibial osteotomy – limited evidence
  18. Free-floating interpositional device – no evidence; consensus against

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