Why females might be more prone to ACL injury.

A risk – factor model for Anterior Cruciate Ligament injury.
Hughes G, Watkins J. Sports Medicine, 2006; 36 (5), 411 – 428.

Amount of non – contact ACL injuries is reported to be higher among females. There is lack of scientific evidence to support why. To answer question why someone might be more susceptible to suffer an injury, number of risk factors are frequently presented. Usually, these are divided into intrinsic and extrinsic. Authors of this review find that categorization limited due to its inability to show how these risk factors interact, which might be crucial in case of ACL injury aetiology. This paper presents a risk – factor model for ACL injuries in female based on analysis of key elements of the passive and dynamic stability support mechanisms.
In regards to passive stability of the knee joint, which may play role in etiology of ACL injury is ligament laxity and geometry of articular surfaces. Q – angle is reported to be greater in females and since greater q- angle means greater knee valgus angle which is said to place ACL at higher stress, one could state that females might be at greater risk of sustaining ACL tear. Authors indicate that some papers found relationship between greater Q –angle and higher risk of ACL ruptures, but others studies refute that notion. Congruence between articular surfaces of the femur and tibia is another factor potentially having an importance here. It might be affected by damaged menisci but there is no evidence that meniscal injury increases the risk of ACL tear (at least up to 2006 when the current paper was published). Tibio – femoral congruence also depends on width of the intercondylar notch (INW): the wider the notch, the lower the congruence. However, some studies reported that females have a smaller INW than males and again some research confirm that those having smaller INW are more susceptible to torn their ACL but other studies do not confirm that, therefore no strong evidence exists to support association between smaller INW and higher ACL rupture incidence among females. Finally, increased knee joint laxity has been proposed to result in higher risk of ACL injury and some studies indicate that females exhibit greater ligamentous laxity than males. It might be in relation to phases of menstrual cycle which possibly affect length and tensile stiffness of ACL, however authors indicate that these findings are inconsistent therefore it cannot be determined whether it plays major role in higher ACL tear occurrence among women.
Dynamic stability risk factors reviewed by authors included the patellar tendon – tibia shaft angle (PTTSA), muscle activity pattern, muscle reaction time, time to peak torque and muscle stiffness. The more knee is extended the greater PTTSA and the greater strain on ACL. Indeed, studies show that ACL injuries occur most frequently when the knee is more extended rather than flexed. Also, some papers note that PTTSA is on average greater in female than male. Given that, authors suggest that higher PTTSA can be regarded as a significant risk factor for ACL rupture in female. Activity of quadriceps and hamstring in dynamic movements should ideally result in zero shear loads on the proximal tibia. Research has found that females exhibit greater quadriceps dominance compared to males therefore place higher anterior shear load on their proximal tibia and subsequently increase ACL strain. Ability of muscles to resist movement in particular joint is called muscle stiffness. Number of studies has found that females demonstrate reduced knee joint muscle stiffness in comparison to males potentially placing their ACL on increased load. Another factor possibly contributing to greater incidence of ACL tears among females is fatigue. Some papers found that fatigued women tended to increase their knee valgus angle as well as tended to decrease their knee flexion angle during landing and other dynamic activities. These factors have been previously suggested to place greater stress on ACL.
In conclusion, authors state that available evidence suggests that greater incidence of ACL ruptures in women may account for sex differences in the dynamic stabilizing structures rather than the passive stability system, although more research is needed to figure out how these factors interact.
Do you treat more women with torn ACL than men? Do you see any other explanation why female might be more susceptible to ACL injury? Are there any differences in yours treatment programs for women and men?
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